One thing for sure, with the tins removed, you'll never have to worrie about them slinging off & destroying the engine.
You'll loose quite a bit of case stuffing with the tins removed from the crank, but there are things you can do that will close the case volume back up.
A big bore cylinder, like 350cc & larger, will displace some of the gained case volume from the tins being removed, from the larger pistons pumping action. Add a larger bore carb, which normally most will do when going big bore & that will displace even more crankcase volume. Something as simple as using alky fuel will displace some volume, not much but some.
All of the 350~370cc cylindered engines in years past that ran TT with us, all I know of had the tins removed & just about everyone of them were front runners winning races.
The tins removed, is a good thing for a strong bottom end big bore engine, the extra volume helps.
Neil