dang i have that exact same question. so would the bigger carb take a noticeable amount from the bottom end?
The big carb will hurt the power below about 4500 RPM. The power will be about the same from 4500 to 6000 RPM. The big carb will usually show a gain above 6500 RPM if your porting and pipe like each other or your engine is modified enough for it to make around 43 hp or more to the rear wheels.
The majority of the good pipes need the RPM to be kept above 6000 RPM to keep the engine "on the pipe".
I define low end to "mean" the beginning of the USABLE POWER CURVE. On the 250R engine, I define the low end of the usable power curve occurs from about 5500 RPM to 6500. Mid range from 6500 to about 7500 RPM and top end from about 7500 to 9000 RPM